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"The Knick" takes place in the heart of New York City in the year 1900 and focuses on the Knickerbocker Hospital and the pioneering surgeons, nurses, and staff members who work there. These individuals push the boundaries of medicine at a time when mortality rates were shockingly high and there were no antibiotics available. Despite the fact that he has a hidden dependence on cocaine, John Thackery is a talented surgeon who is leading the way in the development of novel procedures in the profession. He is the leader of a group of doctors that includes his pupil, Dr. Everett Gallinger; the youthful Dr. Bertie Chickering Jr.; and Dr. Algernon Edwards, an up-and-coming surgeon who has been foisted upon him recently. In addition, there is Cornelia Robertson, who is the daughter of the hospital's benefactor, Captain August Robertson. There is also Tom Cleary, who is a grumpy ambulance driver; Lucy Elkins, who is a young nurse from the country. There is also Herman Barrow, who is a dishonest hospital administrator; and Sister Harriet, who is a nun who isn't afraid to say what's on her mind.